FosB, a Cysteine-Dependent Fosfomycin Resistance Protein under the Control of ς W , an Extracytoplasmic-Function ς Factor in Bacillus subtilis
Open Access
- 1 April 2001
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 183 (7) , 2380-2383
- https://doi.org/10.1128/jb.183.7.2380-2383.2001
Abstract
We demonstrate that the Bacillus subtilis fosB(yndN)gene encodes a fosfomycin resistance protein. Expression offosB requires ςW, and both fosBand sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn2+-dependent glutathione transferases but with a preference for Mg2+ and l-cysteine as cofactors.Keywords
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