Effect of Sodium Copper Chlorophyllin on Lipid Peroxidation. I. Effect on Lipid Peroxidation in Rat Liver Homogenates in the Presence of Both Fe2+ and L-Ascorbic Acid

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Abstract
Effect of sodium copper chlorophyllin (SCC) on lipid peroxidation in rat liver homogenates was examined. Formation of lipid peroxides was estimated by the thiobarbituric acid (TBA) method, and SCC inhibited increases in TBA value caused by Fe2+ and L-ascorbic acid. Fe2+ and ascorbic acid-stimulated lipid peroxidation in liver homogenates was expressed as increase in O2 consumption of liver homogenates. SCC repressed acceleration of O2 consumption of liver homogenates by Fe2+ and ascorbic acid. The antioxidative effect of SCC apparently may not be attributed to free Cu2+ or the pro-oxidative action of SCC on ascorbic acid.