A Carcinogenicity Assay of Mirex in Charles River CD Rats2
- 1 January 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 58 (1) , 133-140
- https://doi.org/10.1093/jnci/58.1.133
Abstract
The long-term administration of 50 and 100 ppm of Mirex in the diets of male and female Charles River CD rats was associated with a spectrum of liver lesions, from foci or areas of cellular alteration and neoplastic nodules to hepatocellular carcinoma. Statistically significant numbers of neoplastic nodules were observed in the livers of male rats receiving the high dose. Neoplastic nodules and hepatocellular carcinomas were not observed in control rats.Keywords
This publication has 2 references indexed in Scilit:
- CELLULAR ANALYSIS OF LIVER CARCINOGENESIS - INDUCTION OF LARGE HYPERPLASTIC NODULES IN LIVER WITH 2-FLUORENYLACETAMIDE OR ETHIONINE AND SOME ASPECTS OF THEIR MORPHOLOGY AND GLYCOGEN METABOLISM1967
- Development of Preneoplastic and Neoplastic Lesions of the Liver in Male Rats Given 0.025 Percent N-2-Fluorenyldiacetamide2JNCI Journal of the National Cancer Institute, 1965