Intolerance to Tartrazine in Aspirin-Induced Asthma: Results of a Multicenter Study
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 53 (1) , 20-23
- https://doi.org/10.1159/000195391
Abstract
One hundred and fifty-six German, Italian and Polish patients with confirmed aspirin-induced asthma underwent open oral challenges with increasing doses of tartrazine up to 25 mg. All positive challenges were repeated under double-blind conditions. Only 4 of 156 patients (all Polish) had positive reactions in a double-blind test, as evidenced by a fall in FEV1 > 25% from baseline and corresponding clinical symptoms. Sixty-five patients who tolerated 25 mg tartrazine well received 50–3,000 mg tartrazine and none showed adverse reactions. Thus, intolerance to tartrazine appears to be rare among Central-European and South-European patients with aspirin-induced asthma, its frequency amounting to about 2.6%.Keywords
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