Control of oral anticoagulant treatment by chromogenic prothrombin assay.
- 1 May 1987
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 40 (5) , 500-504
- https://doi.org/10.1136/jcp.40.5.500
Abstract
Doses of oral anticoagulants in 50 patients on long term treatment were easily and satisfactorily monitored over six months by an automated chromogenic assay of prothrombin (CPA). It is suggested that chromogenic assay of one or more of the vitamin K dependent coagulation factors would provide a readily standardised alternative to those conventional tests which depend on human brain derived reagents, now regarded as a biohazard.This publication has 26 references indexed in Scilit:
- CREUTZFELDT-JAKOB DISEASE PATHOGEN IN GROWTH HORMONE PREPARATIONS IS ELIMINATABLEThe Lancet, 1985
- STRUCTURES RESEMBLING SCRAPIE-ASSOCIATED FIBRILS IN AIDS ENCEPHALOPATHYThe Lancet, 1985
- ANTI-HTLV-III POSITIVE LABORATORY REAGENTSThe Lancet, 1985
- Therapeutic ranges in anticoagulant administration.BMJ, 1985
- Evaluation of an Automated Prothrombin Assay Using a Chromogenic SubstratePathophysiology of Haemostasis and Thrombosis, 1984
- Standardisation of oral anticoagulant treatment.BMJ, 1983
- Use of Chromogenic Peptide Substrates in the Determination of Clotting Factors II, VII, IX and X in Normal Plasma and in Plasma of Patients Treated with Oral AnticoagulantsPathophysiology of Haemostasis and Thrombosis, 1982
- Control of Anticoagulant Therapy with a Chromogenic SubstratePathophysiology of Haemostasis and Thrombosis, 1979
- Validity of the British system for anticoagulant control using the national reagentJournal of Clinical Pathology, 1970
- Turnover of Prothrombin, Factor VII and Factor IX in a Patient with Hemophilia AScandinavian Journal of Clinical and Laboratory Investigation, 1961