Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases
- 1 December 2005
- journal article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 46 (12) , 4393-4401
- https://doi.org/10.1167/iovs.05-0820
Abstract
Purpose. Excessive accumulation of lipofuscin is observed in numerous degenerative retinal diseases. A toxic vitamin A–based fluorophore (A2E) present within lipofuscin has been implicated in the death of RPE and photoreceptor cells. Here, we used an animal model that manifests accelerated lipofuscin accumulation (ABCA4−/− mutant) to evaluate the efficacy of a therapeutic approach based on reduction of serum retinol.Keywords
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