ON THE INTERACTION OF OESTRIN AND THE OVARY-STIMULATING PRINCIPLES OF EXTRACTS OF THE URINE OF PREGNANCY

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Abstract
It was observed that oestrin is directly antagonistic to follutein when both are injected into ovariectomized mice. A similar effect is had when the ovary-stimulating hormone is antuitrin S. No definite suppression was had of follutein effects on the ovaries of immature mice when 10 or 20 m.u. of oestrin were injected simultaneously with the follutein (4 m.u.). A technique for studying hormonic antagonism and interaction is presented. The general method is as follows: Extirpation of the gland studied; study of effects of removal; replacement therapy by injection of hormone of that gland; then simultaneous injection of other hormones to see which of them suppresses or enhances the replacement effect of the first hormone.