Single-dose ceftriaxone kinetics in functionally anephric patients
- 1 May 1983
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 33 (5) , 633-641
- https://doi.org/10.1038/clpt.1983.86
Abstract
The disposition profile of ceftriaxone was studied in 12 functionally anephric patients (creatinine clearance FNR) identical to those in healthy adults and only minor increases in their biologic t½(β) compared to normal (12 and 8 hr). These patients would require no dose adjustments in their dosing regimen. Two of the patients exhibited decreased ClFNR values and increased t½(α) of 20 and 34 hr. Anephric patients with impaired nonrenal elimination would require minor dose adjustments. Clinical Pharmacology and Therapeutics (1983) 33, 633–641; doi:10.1038/clpt.1983.86This publication has 7 references indexed in Scilit:
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