Eight Novel Sterols from the Roots of Bryonia dioica JACQ.
- 1 January 1996
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 44 (6) , 1202-1207
- https://doi.org/10.1248/cpb.44.1202
Abstract
Eight novel sterols, 4, 4-dimethyl-5α-poriferasta-7, 25-dien-3β-ol, (24E)-24-ethyl-29-nor-5α-lanosta-7, 24(241)-dien-3β-ol, (24E)-24-ethyl-29-nor-5α-lanosta-9(11), 24(241)-dien-3β-ol, (24E)-24-ethyl-29-nor-5α-lanosta-7, 9(11), 24(241)-trien-3β-ol, (22E, 24Z)-5α-stigmasta-7, 22, 24(241)-trien-3β-ol, 5α-stigmasta-7, 9(11)-dien-3β-ol, (24E)-5α-stigmasta-7, 9(11), 24(241)-trien-3β-ol, and (24E)-14α-methyl-5α-stigmasta-7, 24(241)-dien-3β-ol, were isolated (as acetates) from the saponified neutral fraction of Bryonia dioica root extract. The structures were determined by spectroscopic methods. The compounds are new because the 4, 4-dimethy-Δ7-cholestene-, 4α, 14α-dimethyl-Δ7-cholestene (or 29-nor-Δ7-lanostene)-, and 14α-methyl-Δ7-cholestene-skeletons and the (22E, 24Z)-Δ22, 24(241)-stigmastadiene side chain have not been found before in nature. Abundances are given of fifty three identified triterpene alcohols and sterols.Keywords
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