Sustained release of insulin from a hydrophilic polymer matrix implanted in diabetic rats.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (9) , 3689-3691
- https://doi.org/10.1248/cpb.36.3689
Abstract
A long-acting insulin preparation involving the sustained release of biologically active insulin from a hydrophilic ethylene-vinyl alcohol (EVA) matrix was developed. A single subcutaneous implant of this insulin lowered the blood glucose levels of diabetic rats for more than one month. These results suggest that a long-acting insulin may be produced by the entrapment of insulin within a hydrophilic EVA1 copolymer matrix.This publication has 3 references indexed in Scilit:
- Antitumor effect of implanted ethylene-vinyl alcohol copolymer matrices containing anticancer agents on Ehrlich ascites carcinoma and P388 leukemia in mice.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
- Controlled release of 5-fluorouracil from hydrophilic ethylene-vinyl alcohol copolymer matrices.CHEMICAL & PHARMACEUTICAL BULLETIN, 1983
- One month of sustained release of insulin from a polymer implantDiabetes, 1980