Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor
- 1 December 1990
- journal article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 342 (6) , 722-724
- https://doi.org/10.1007/bf00175719
Abstract
Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9 and 6.0, respectively. [D-Pro2, D-Trp7,9]-substance P, a competitive tachykinin antagonist, had pA2 values of 5.3 against neurokinin A, 5.1 against neurokinin B and 5.2 against substance P indicating that tachykinin receptors mediated responses to the agonists. [pGIu5,MePhe8,-McGly9]-substance P 5–11 (DiMe-C7), senktide and septide did not contract the aorta. It is concluded that of the known tachykinin receptors smooth muscle of the rabbit isolated aorta contains only the NK-2 type.Keywords
This publication has 18 references indexed in Scilit:
- Receptors for neurokinins in human bronchus and urinary bladder are of the NK-2 typeEuropean Journal of Pharmacology, 1990
- Characterization of Neurokinin Effects and Receptor Selectivity in Human Isolated BronchiAmerican Review of Respiratory Disease, 1989
- New selective agonists for neurokinin receptors: pharmacological tools for receptor characterizationTrends in Pharmacological Sciences, 1988
- Characterization of neurokinin receptors in various isolated organs by the use of selective agonistsLife Sciences, 1987
- Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance and related neurokininsEuropean Journal of Pharmacology, 1986
- The contractile activities of neurokinin A, B and related peptides on smooth musclesEuropean Journal of Pharmacology, 1986
- Receptors for substance P. III. Classification by competitive antagonistsEuropean Journal of Pharmacology, 1984
- THE MECHANISM OF ACTION OF A SUBSTANCE P ANTAGONIST (D-Pro2, D-Trp7,9)-SPBritish Journal of Pharmacology, 1982
- Pharmacological characterization of four related substance P antagonistActa Physiologica Scandinavica, 1982
- SOME QUANTITATIVE USES OF DRUG ANTAGONISTSBritish Journal of Pharmacology and Chemotherapy, 1959