A Minute Deletion of the Y Chromosome in Men with Azoospermia
- 1 October 1993
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 150 (4) , 1155-1157
- https://doi.org/10.1016/s0022-5347(17)35712-9
Abstract
We analyzed deoxyribonucleic acid from 50 Japanese men with azoospermia whose Y chromosomes were cytogenetically normal. A total of 26 loci was examined in each patient. Of these patients 6 had small interstitial deletions, each of which was located within the distal part of Yqll. Five of these 6 patients lacked the same 2 loci, DYS7C and DYS1, while 1 patient had a larger deletion including DYS7C but not DYS1. More than 10% of all men with azoospermia of unknown origin may have minute interstitial deletions of the Y chromosome surrounding the DYS7C locus. The proximal part of this zone presumably encompasses the gene deletion that causes azoospermia.Keywords
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