Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy
- 27 May 1983
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4600) , 974-977
- https://doi.org/10.1126/science.6133351
Abstract
Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.Keywords
This publication has 46 references indexed in Scilit:
- A Liquid Chromatographic Assay for 5‐Hydroxytryptophan, Serotonin and 5‐Hydroxyindoleacetic Acid in Human Body FluidsActa Pharmacologica et Toxicologica, 1982
- Cytomegalovirus Antibody in Cerebrospinal Fluid of Schizophrenic Patients Detected by Enzyme ImmunoassayScience, 1982
- Homovanilic acid in Huntington's disease and Sydenham's chorea.Journal of Neurology, Neurosurgery & Psychiatry, 1981
- II. Validity and reliability of liquid chromatography with electrochemical detection for measuring plasma levels of norepinephrine and epinephrine in manLife Sciences, 1981
- CHARACTERISTICS OF PATIENTS WITH SCHIZOPHRENIA OR NEUROLOGICAL DISORDER AND VIRUS-LIKE AGENT IN CEREBROSPINAL FLUIDThe Lancet, 1979
- The dopamine hypothesis of schizophrenia revisitedPsychoneuroendocrinology, 1979
- Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitroLife Sciences, 1978
- Amine metabolites in the cerebrospinal fluid in Huntington's choreaJournal of Neurology, Neurosurgery & Psychiatry, 1972
- Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in psychiatric patientsInternational Journal of Neuropharmacology, 1969
- Schizophrénie et involution cérébrale sénileEuropean Neurology, 1967