Gonadotropin Releasing Hormone Analogue and Growth Hormone Therapy in Precocious and Premature Puberty following Cranial Irradiation for Acute Lymphoblastic Leukaemia
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 39 (1-2) , 25-29
- https://doi.org/10.1159/000182690
Abstract
Ten girls with early puberty secondary to cranial irradiation as a part of the treatment for acute lymphoblastic leukaemia (ALL) were treated with either gonadotropin-releasing hormone analogue (GnRHa) and human growth hormone (GH) (8 girls) or with GnRHa alone (2 girls). After 4 years of treatment, height SDS for bone age was improved in the group who received combined treatment (from -0.97 to +0.07, pKeywords
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