Renal tubular transport of fluoride compared with chloride

Publisher Website
Google Scholar
Abstract
Simultaneous clearances of inulin, chloride, and radiofluoride (F18), given by priming injection and constant infusion, were measured in dogs depleted of chloride, undergoing mannitol or sulfate diuresis, and after chloride repletion. In the presence of appreciable chloruresis, fluoride and chloride reabsorption varied together independently of flow. However, when chloride reabsorption was nearly complete ( >99%), fluoride reabsorption became dependent on flow, urine-to-plasma concentration ratio averaging 1.6. It is inferred that passive reabsorption of fluoride occurs proximally, tubular permeability to fluoride being much less than to chloride, but that fluoride does not share in the distal tubular transport of the last traces of chloride.

This publication has 9 references indexed in Scilit: