Decoding the ‘black box’ reactivity that is organocuprate conjugate addition chemistry

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Abstract
Understanding of the 1,4-addition of organocuprates, especially LiCuR2 species, to enone Michael acceptors has blossomed in the light of recent kinetic, NMR, and theoretical investigations. These investigations have been reviewed and are compared to the various reaction co-ordinates they support. Emphasis is placed on relating the theoretical calculations to physical data extracted from real systems. The mechanism of cuprate conjugate addition is compared to related reactions including: additions to ynones, alkene carbocupration, and SN2′ allylic and propargylic substitution reactions.

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