Cell type–specific gating of perisomatic inhibition by cholecystokinin
Open Access
- 5 August 2007
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 10 (9) , 1128-1130
- https://doi.org/10.1038/nn1952
Abstract
Parvalbumin- and cholecystokinin (CCK)-expressing basket cells provide two parallel, functionally distinct sources of perisomatic inhibition to postsynaptic cells. We show that exogenously applied CCK enhances the output from rat parvalbumin-expressing basket cells, while concurrently suppressing GABA release from CCK-expressing neurons through retrograde endocannabinoid action. These results indicate that CCK may act as a molecular switch that determines the source of perisomatic inhibition for hippocampal principal cells.Keywords
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