Common variants in WFS1 confer risk of type 2 diabetes
- 1 July 2007
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (8) , 951-953
- https://doi.org/10.1038/ng2067
Abstract
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.Keywords
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