Identification and characterisation of a novel splice variant of the human CB1 receptor
- 8 December 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (1) , 259-264
- https://doi.org/10.1016/j.febslet.2004.11.085
Abstract
Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.Keywords
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