Mothers Setting Boundaries
- 23 June 2000
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 288 (5474) , 2145-2146
- https://doi.org/10.1126/science.288.5474.2145
Abstract
Certain genes are only expressed at one allele, a phenomenon called imprinting. Although it is well established that one allele of certain imprinted genes is silenced through methylation, this does not appear to be the case for all imprinted genes. In a thoughtful Perspective, Thorvaldsen and Bartolomei discuss new findings showing that insertion of insulator elements (boundary regions) between the promoter of a gene and its enhancer (a sequence that boosts gene expression) may be another way in which genes are silenced during imprinting.Keywords
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