The Role of Platelets in Fibrinolysis

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Abstract
Inhibition of plasmin and activation of plasminogen by platelet‐poor plasma, intact, lysed and thrombin‐aggregated platelet‐rich plasma, and washed platelets was studied by means of fibrin‐agar plates. No significant activation of plasminogen by platelets could be demonstrated. Maximal inhibition of plasmin occurred after 2–3 hr incubation with either platelet‐rich or platelet‐poor plasma; in each case the kinetics of the reaction were suggestive of non‐competitive inhibition. Platelets showed both adsorbed and intrinsic anti‐plasmin activity, but the latter was equivalent to only about 1% of the total plasma activity.

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