Activities of Alkoxyalkyl Esters of Cidofovir (CDV), Cyclic CDV, and ( S )-9-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine against Orthopoxviruses in Cell Monolayers and in Organotypic Cultures
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7) , 2525-2529
- https://doi.org/10.1128/aac.01489-05
Abstract
The potencies of several alkoxyalkyl esters of acyclic nucleoside phosphonates against vaccinia virus and cowpox virus were evaluated in cell monolayers and three-dimensional epithelial raft cultures. Prodrugs were at least 20-fold more active than their parent compounds. Octadecycloxyethyl-( S )-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine emerged as the most potent derivative.This publication has 17 references indexed in Scilit:
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