Regulation of interleukin-6 receptor expression by interleukin-6 in human monocytes - a re-examination
- 30 May 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 345 (2-3) , 131-134
- https://doi.org/10.1016/0014-5793(94)00416-1
Abstract
We have studied the expression and regulation of the interleukin-6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin-6 (IL-6) lead to a down-regulation of IL-6 receptor mRNA in monocytes. Also in the human monocytic cell line Mono Mac 6 no effect of IL-6 on receptor mRNA levels was observed. For signal transducer gp13O mRNA in monocytes a small and transient up-regulation by IL-6 was found.Keywords
This publication has 23 references indexed in Scilit:
- The hepatic interleukin‐6 receptor Down‐regulation of the interleukin‐6 binding subunit (gp80) by its ligandFEBS Letters, 1992
- Enhancement of IL-6 receptor β chain (gp130) expression by IL-6, IL-1 and TNF in human epithelial cellsBiochemical and Biophysical Research Communications, 1992
- Up‐regulation of interleukin (IL)‐6 receptor gene expression in vitro and in vivo in IL‐6 deprived myeloma cellsFEBS Letters, 1992
- Up‐regulation of the interleukin‐6‐signal transducing protein (gp130) by interleukin‐6 and dexamethasone in HepG2 cellsFEBS Letters, 1992
- Expression of functional receptors for interleukin-6 by human polymorphonuclear, leukocytes Downregulation by granulocyte-macrophage colony-stimulating factorFEBS Letters, 1991
- Molecular cloning and expression of an IL-6 signal transducer, gp130Cell, 1990
- Interleukin-6: An OverviewAnnual Review of Immunology, 1990
- Regulation of interleukin‐6 receptor expression in human monocytes and hepatocytesFEBS Letters, 1989
- Production of hybridoma growth factor by human monocytesEuropean Journal of Immunology, 1987
- The inflammation mediators interleukin 1 and hepatocyte‐stimulating factor are differently regulated in human monocytesEuropean Journal of Immunology, 1987