Effect of Inoculation with H. Pertussis Vaccine on Susceptibility of Albino Mice to 5-Hydroxytryptamine (Serotonin)

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Abstract
The systematic toxicity of 5-hydroxytryptamine (serotonin) to albino mice is of low order, the LD50 by the intraperitoneal route being 542 (439-728) mg/kg. Pre-treatment with Haemophilus pertussis phase I organisms increases significantly the susceptibility to serotonin, the LD50 on the 4th day after the inoculation being reduced to 14.5 (6.2-19.5) mg/kg. The same pre-treatment also renders mice considerably more susceptible to histamine and to active and passive anaphylaxis. The possible role of serotonin alongside histamine as a mediator in anaphylactic processes is discussed.