EFFECT OF ACUTE PHYSICAL OVERHEATING OF ANIMALS ON PEROXIDATION OF LIPIDS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 22  (1) , 47-51
Abstract
In liver tissue, brain, lungs and skeletal muscles of rats subjected to overheating, the content of conjugated dienes and lipid peroxides was distinctly increased. The decrease in the period of malondialdehyde induction and in the antioxidative activity of lipids correlated with the alteration in the content of peroxidation products. Overheating of animals was accompanied by a decrease in the unsaturation of lipids in liver tissue, brain and skeletal muscles due to a decrease in the amounts of arachidonic acid and to an increase in the content of palmitinic and stearinic acids. In the lipids of the lungs the unsaturation was increased as a result of increase in the content of linoleic acid. Administration of .alpha.-tocopherol and ionol, 10 min before the overheating and in hypothermia, exhibited a protective effect; thioTEPA had the opposite action. Administration of .alpha.-tocopherol and ionol 24 h before the thermic treatment decreased the survival period of the animals subjected to overheating.