N-|(1,5,9)-trimethyl-decyl|-4α, 10-dimethyl-8-aza-trans-decal-3β-ol a novel potent inhibitor of 2,3-oxidosqualene cycloartenol and lanosterol cyclases
- 1 July 1986
- journal article
- research article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 138 (2) , 764-770
- https://doi.org/10.1016/s0006-291x(86)80562-9
Abstract
No abstract availableThis publication has 10 references indexed in Scilit:
- In vitro inhibition of animal and higher plants 2,3-oxidosqualene-sterol cyclases by 2-aza-2,3- dihydrosqualene and derivatives, and by other ammonium-containing moleculesBiochemical Pharmacology, 1985
- Time-dependent inhibition of isopentenyl pyrophosphate isomerase by 2-(dimethylamino)ethyl pyrophosphateJournal of the American Chemical Society, 1985
- Inhibition of δ8 → δ7-sterol isomerase and of cycloeucalenol—obtusifoliol isomerase by N-benzyl-8-aza-4α, 10-dimethyl-trans-decal-3β-ol, an analogue of a carbocationic high energy intermediatePhytochemistry, 1985
- Inhibition of S-adenosyl-L-methionine sterol-C-24-methyltransferase by analogues of a carbocationic ion high-energy intermediate. Structure activity relationships for C-25 heteroatoms (N, As, S) substituted triterpenoid derivatives.Journal of Biological Chemistry, 1984
- Squalene synthetase. Inhibition by an ammonium analogue of a carbocationic intermediate in the conversion of presqualene pyrophosphate to squaleneJournal of the American Chemical Society, 1982
- 24-Methyl-25-azacycloartanol, an analog of a carbonium ion high-energy intermediate, is a potent inhibitor of (S)-adenosyl-L-methionine: sterol C-24-methyltransferase in higher plant cellsJournal of the American Chemical Society, 1981
- A novel inhibitor of steroid biosynthesisJournal of the American Chemical Society, 1978
- TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSISAnnual Review of Biophysics and Bioengineering, 1976
- Molecular Architecture and Biological ReactionsPublished by American Chemical Society (ACS) ,1946