Deficiency of Hepatic Organic Anion-Binding Protein, Impaired Organic Anion Uptake by Liver and Physiologic Jaundice in Newborn Monkeys

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Abstract
The possibility that "physiologic" jaundice in monkeys results from immaturity of the hepatic organic anion-uptake process was investigated by serial measurement of the initial plasma clearance of intravenously administered bromsulfalein (BSP), the serum bilirubin concentration and the hepatic intracellular concentration of Y and Z, two cytoplasmic organic anion-binding proteins.