Effects of a transplantable insulinoma upon regulatory peptide concentrations in the gastrointestinal tract of the rat
- 1 May 1986
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 29 (5) , 334-338
- https://doi.org/10.1007/bf00452072
Abstract
The rapid growth (0.8±0.3 g/day) of a transplantable insulinoma, which also contained substance P (2.9±2.3 pmol/g) and gastrin-releasing peptide (3.2± 2.1 pmoll/g), resulted in the development of hyperphagia, hyperinsulinaeinia and hypoglycaemia in rats (n=8). After a 14-day growth period, the insulinoma-bearing rats showed an increase (49%; ppppppp<0.05) in the insulinoma rats.Keywords
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