TRANSPLANTATION OF CHEMICALLY-INDUCED GASTRIC CANCER IN WISTAR RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 67  (3) , 365-369
Abstract
Seven of 35 male Wistar rats developed well differentiated adenocarcinoma of the glandular stomach on combined treatment with N-methyl-N''-nitro-N-nitrosoguanidine and 4-nitroquinoline-1-oxide. One of the tumors was successfully transplanted into newborn Wistar rats by s.c. inoculation. The latent period after inoculation was less than 1 mo., and the growth of the transplanted tumor was slow throughout 10 transplant generations. The tumor appeared nodular or cystic in subcutaneous tissues of rats and often caused ulceration of the skin. The histology of transplanted tumors was similar to that of the primary tumor. Metastases to both lungs were observed in 1 rat of the 1st transplant generation.

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