An iconoclastic view of conventional wisdoms in hematology
- 1 February 1979
- journal article
- editorial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 139 (2) , 221-223
- https://doi.org/10.1001/archinte.139.2.221
Abstract
Several widely held views in modern medicine were discussed as becoming irrelevant in the future. These included the following: patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency should not be given sulfisoxazole, aspirin or chloroquine since these drugs may precipitate a hemolytic reaction; histopathologic classification of lymphomas is essential to good patient management; bone marrow transplantation is acceptable therapy for severe aplastic anemia when all else fails, and its use in acute granulocytic leukemia (AGL) is highly experimental and should be limited to patients suffering from drug-resistant relapse; defects of the hexose monophosphate pathway, including deficiencies of G-6-PD, reduced glutathione, glutathione peroxidase, glutathione reductase and 6-phosphogluconate dehydrogenase are characterized by sensitivity to drug-induced hemolytic anemia; in patients receiving aggressive chemotherapy, platelet transfusions should be given when the platelet count declines to less than 20,000/cu mm.This publication has 0 references indexed in Scilit: