Clinical, Pathological and Molecular Genetic Findings in Small Intestinal Follicle Centre Cell Lymphoma
Open Access
- 1 January 1997
- journal article
- case report
- Published by Hindawi Limited in Canadian Journal of Gastroenterology and Hepatology
- Vol. 11 (1) , 31-34
- https://doi.org/10.1155/1997/507318
Abstract
A 44-year-old male was evaluated for an iron deficiency anemia. Endoscopic investigation revealed marked serpiginous ulceration of the proximal small intestine due to a B cell lymphoma. Endoscopic small intestinal mucosal biopsies revealed a nodular lymphoid infiltrate, and polymerase chain reaction of biopsy material from the same site demonstrated rearrangement of thebcl-2gene, the molecular equivalent of the t(14;18) chromosomal translocation. Primary small bowel follicular small cleaved cell lymphoma was diagnosed. Endoscopic tissue biopsies for immunophenotyping, molecular genetic studies or both are a valuable diagnostic aid for precise classification of lymphoid neoplasms in the gastrointestinal tract.Keywords
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