Long-Term Effect of Dialysate Calcium and 1α-Hydroxycholecalciferol on Bone Calcium Content in Haemodialysis Patients as Measured by Neutron Activation Analysis of the Forearm

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Abstract
The effect of different concentrations of dialysate calcium and treatment with 1α-OHD3 on bone calcium content in haemodialysis patients was investigated over a 2½-year period. Part-body neutron activation analysis of the forearm with 252Cf was used to measure both an initial absolute calcium content and changes in the bone calcium. A highly significant inverse correlation (r = –0.84, p < 0.001) was found between the initial calcium content and the duration of previous dialysis utilising a dialysate calcium concentration of 1.75 mmol/l. No significant difference was found between the changes in bone calcium in patients who continued using a dialysate calcium of 1.75 mmol/l and those whose dialysate calcium was reduced to 1.375 mmol/l. There was a significant increase of 16.7% (p < 0.01) in bone calcium over the 2½-year period in the patients receiving 1α-OHD3. The results of the study suggest that bone calcium loss is not necessarily influenced by dialysate calcium concentration but that 1α -OHD3 has a beneficial long-term effect on bone calcium content.

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