Aplastic Anemia and Sulindac

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Abstract
To the editor: Miller (1) has reported a case of aplastic anemia apparently related to sulindac therapy. We recently saw a 62-year-old woman with pancytopenia associated with sulindac therapy. The patient's severe rheumatoid arthritis had become refractory to salicylate therapy 2 years earlier, and she was given Ibuprofen followed by naproxen. The latter was discontinued after 8 months, and sulindac, 400 mg daily, was begun, with marked symptomatic improvement. Three months later the patient noted increasing shortness of breath, fatigability, and palpitations. She was not using any other medication. Physical examination showed generalized pallor. Several ecchymoses were present over the

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