Commentary: The HRT story: vindication of old epidemiological theory
Open Access
- 27 May 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 33 (3) , 456-457
- https://doi.org/10.1093/ije/dyh121
Abstract
In 1995, a long time before any result of any randomized controlled trial would be known, I wrote that about half of the alleged 35–45% reduction of myocardial infarction with hormone replacement therapy (HRT) in observational studies would not be real.1 Still, I should confess that the total reversal of the effect—a slight increase of myocardial infarction in the first years of use—took me also by surprise.Keywords
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