The Removal of Dietary Chylomicrons and Artificial Fat Emulsions from the Circulation of Rats

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Abstract
The purpose with the investigation was to compare the removal of three different artificial intravenous fat emulsions from the blood of nonfasted rats with the removal from blood of washed chylomicrons collected from rats fed cottonseed oil. The injected dose of glycerides varied between 300 and 1,000 mg/kg body weight. The elimination pattern of the injected particulate fat was determined turbidimetrically. The chylomicrons as well as the different emulsions showed an exponential type of disappearance during the major part of the elimination process. Two of the tested emulsions contained vegetable oil stabilized with phospholipids. These emulsions showed an elimination rate very similar to that of chylomicrons. The third emulsion (“SR”), lacking phospholipids and containing vegetable oil stabilized with synthetic agents, disappeared from blood significantly faster than chylomicrons. With all the injected substrates the elimination rate decreased with increasing fat loads.