Measurement of coronary blood flow by coincidence counting and a bolus of 84RbCl

Publisher Website
Google Scholar
Abstract
The coronary blood flow (CBF) in dogs was studied using a coincidence-counting system and a single bolus technique of isotope injection. Experiments were carried out on 10 dogs. A bolus of Rb84Cl was injected into the superior vena cava and coronary blood flow was determined by dividing the myocardial uptake as counted externally by the integrated arterial curve, completed by semilogarithmic extrapolation of the 1st circulation downs lope. The measurement was compared to CBF as determined by the Fick method and was found to vary from + 9.9 to - 7.9% with a mean absolute error 5.3%. The results could be repeated in the same animal within [plus or minus]3%. The theoretical basis for the technique is discussed and evidence given that coronary blood flow can be determined as a fraction of the cardiac output providing the myocardium has an extraction ratio which does not differ significantly from the whole body extraction ratio.