Hypercholesterolaemia and thyroid hormone status

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Abstract
Hypercholesterolaemia, through its association with coronary heart disease, is currently a major health problem in Western Society. If the recommendations of the British Hyperlipidaemia Association and its American counterparts are to be followed, it has been estimated that 49% of males over 40 years of age in the U.K. should modify their diet in an attempt to reduce their hypercholesterolaemia (Shepherd, Betteridge, Durrington et al. 1987; Shaper & Pocock, 1985). Additionally, as many as 31% may also require drug therapy (Shaper & Pocock, 1985), although others would not support medication on such a large scale (Jones, Hughes, Cramb & Clapham, 1988). For over 50 years, changes in the serum cholesterol concentration have been a well-recognized feature in disturbances of thyroid function (Mason, Hunt & Hurxthal, 1930). In hypothyroidism, hypercholesterolaemia results from increases in circulating amounts of cholesterol in very low density lipoprotein, low density lipoprotein (LDL) and high density lipoprotein

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