A syndrome characterized by nodular, tender, itching panniculitis has been recently described after massive prednisone therapy for rheumatic fever. In this report 4 additional cases of this syndrome are described. The episodes reported were milder, and occurred after less massive prednisone administration, as compared with the original cases. In 3 cases the lesions left a pigmented area in the skin. In none a depressed scar occurred, as would be expected in the Weber-Christian syndrome. The lesions did not affect the extensor surface of the limbs, as would be expected in erythema nodosum. The clinical and histologic characteristics of this syndrome have previously permitted a differentiation from rheumatic rebounds. This differentiation is made more evident by the observation, in 2 of the cases here reported, of both a clinical rheumatic rebound and a post-steroid panniculitis, occurring at different times after stopping steroid administration.