Butyric monosaccharide ester‐induced cell differentiation and anti‐tumor activity in mice. Importance of their prolonged biological effect for clinical applications in cancer therapy
- 19 August 1991
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 49 (1) , 89-95
- https://doi.org/10.1002/ijc.2910490117
Abstract
The interest of butyric salts is based on their capacity to promote differentiation of malignant cells and inhibition of tumor development. The phenotypic modifications are rapidly reversible and require the continuous presence of butyric salts in the target area, which raises problems for therapeutic applications. We show here that the covalent binding of n-butyric acid on natural polyhydroxylated compounds such as monosaccharides, especially 3- or 6-O-butanoyl- 1,2-O-iropro-pylidene-α-D-glucofuranose, retains the majority of the biological properties of n-butyric acid. The delayed degradation of these covalent compounds is associated with an improved maintenance of cell differentiation and anti-tumor protection in mice. These butyric complexes thus seem potentially useful for therapeutic applications.Keywords
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