Changes in reliability of synaptic function as a mechanism for plasticity
- 1 October 1994
- journal article
- Published by Springer Nature in Nature
- Vol. 371 (6499) , 704-707
- https://doi.org/10.1038/371704a0
Abstract
Synaptic transmission in the hippocampus is rather unreliable, with many presynaptic action potentials failing to release neurotransmitter. How is this unreliability affected by the alterations in synaptic strength seen in long-term potentiation (LTP) and long-term depression (LTD)? We find that LTP increases synaptic reliability, and LTD decreases it, both without a change in the size of those postsynaptic currents that do occur. Thus LTD is a functional inverse of LTP.Keywords
This publication has 16 references indexed in Scilit:
- The probability of transmitter release at a mammalian central synapseNature, 1993
- Nonuniform Probability of Glutamate Release at a Hippocampal SynapseScience, 1993
- Reversal of long-term potentiation by inhibitors of haem oxygenaseNature, 1993
- Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampusPublished by Elsevier ,1992
- Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant MiceScience, 1992
- Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currentsNature, 1992
- Putative Single Quantum and Single Fibre Excitatory Postsynaptic Currents Show Similar Amplitude Range and Variability in Rat Hippocampal SlicesEuropean Journal of Neuroscience, 1992
- Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slicesNature, 1990
- Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiationNature, 1986
- Hippocampal long‐term potentiation is induced by pairing single afferent volleys with intracellular^ injected depolarizing current pulsesActa Physiologica Scandinavica, 1986