Malignant neoplasms in rats fed lasiocarpine

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Abstract
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/106 for 55 wk, to 20 male F-344 rats. Malignant tumors developed in 17/20 animals between 48 and 59 wk. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumors included malignant adnexal tumor of the skin (1 rat) and lymphoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and 1 animal with hepatocellular carcinoma. From 1 animal, angiosarcoma was successfully transplanted through 4 generations.