INHERITANCE OF HYPERTROPHIC PYLORIC STENOSIS

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Abstract
A family is reported in which the mother and 3 of her 5 children have a history of hypertrophic pyloric stenosis. The inheritance and roentgenographic signs of hypertrophic pyloric stenosis are discussed. The more recent genetic studies support the theory that hypertrophic pyloric stenosis is inherited as a dominant polygenic trait and that the threshold level for expression of the disease state is lower for males than for females. However, females that have hypertrophic pyloric stenosis carry a greater number of genes for the condition than a comparable male and have a greater risk of producing affected children.

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