ON THE METABOLISM OF DIHYDROXYACETONE IN PANCREATIC DIABETES

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Abstract
When administered to fasting depan-creatized dogs deprived of insulin, dihydroxyacetone is quantitatively excreted as glucose. This conversion requires no insulin, and no antiketogenic action occurs. After administration of the triose it appears in the blood and the true blood sugar rises, even though the animal is already hyperglycemic, pari passu with the disappearance of the triose. The respiratory quotient did not rise during observation, though that of the triose itself is unity. This in conjunction with evidence reported elsewhere supports general conclusion that dihydroxyacetone is metabolized through glucose, is not an intermediary catabolite of glucose, and possesses no greater value in diabetic treatment than glucose itself.

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