Distribution and Excretion of F18 Fluoride in Beef Cattle

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Abstract
Blood, saliva, urine and fecal samples from two beef heifers and 12 mature beef cows given tracer levels of F18 showed that F18 was distributed and excreted rapidly. After 2 min., 53% of the dose remained in the blood, but after 240 min., only 4% of the dose remained in the blood. The F18 in the protein-free filtrate was higher than in the plasma or cells. Tissue samples taken at 240 min. after dosing showed high concentrations of F18 in lung, kidney, rumen wall, reticular wall and in bone. Continued feeding of fluoride did not influence metabolism or excretion of F18. Stable fluoride varied with the levels of fluoride fed.

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