SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
- 1 November 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (21) , 5263-5267
- https://doi.org/10.1016/j.bmcl.2004.08.034
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa InhibitorJournal of Medicinal Chemistry, 2003
- Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor XaJournal of Medicinal Chemistry, 2001
- Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate bindingStructure, 1999
- An Inhibitory Anti-factor IX Antibody Effectively Reduces Thrombus Formation in a Rat Model of Venous ThrombosisThrombosis and Haemostasis, 1999
- Thrombin and factor Xa inhibitorsDrugs of the Future, 1998
- Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinantsThe EMBO Journal, 1997
- Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcoholsFEBS Letters, 1997
- Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein CThrombosis and Haemostasis, 1997
- X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.Proceedings of the National Academy of Sciences, 1995
- New Compounds. Syntheses from AcetoheterocyclesJournal of the American Chemical Society, 1948