Nucleoside Analogs. II. A Synthesis of 9-Adenyl-deoxyinositols
- 1 June 1971
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 44 (6) , 1695-1697
- https://doi.org/10.1246/bcsj.44.1695
Abstract
Four 9-adenyl-deoxyinositols were prepared by a reaction between 4-amino-6-chloro-5-nitropyrimidine (1) and inosamines (2a, 2b, 2c, and 2d), followed by a reduction and a cyclization. In the present article, 1-(6′-amino-9′-purinyl)-1-deoxy-scyllo-inositol (5a), 1-(6′-amino-9′-purinyl)-1-deoxy-muco-inositol (5b), 2-(6′-amino-9′-purinyl)-2-deoxy-epi-inositol (5c), and 2-(6′-amino-9′-purinyl)-2-deoxy-myo-inositol (5d) were described. These compunds exhibited an inhibitory effect against piricularia oryzae.Keywords
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