INTOXICATION WITH VITAMIN D

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Abstract
11 cases of intoxication by prepns. of vit. D are reported. The symptomatology and pathologic physiology of this condition are discussed. The wide variation in susceptibility of patients to these drugs is emphasized. Ocular manifestations, subconjunctival deposits and lesions of "band keratitis" may be visible on slit-lamp examination before symptoms of intoxication or signs of renal irritation appear. It is believed that the hypercalcemia is largely responsible for the symptoms and signs of vit. D poisoning, but the mechanisms by which the hypercalcemia is induced remain obscure. Patients to whom these drugs are administered should be carefully followed by frequent slit-lamp examination, urinary analyses and detns. of the serum Ca.