SHV-14, a Novel β-Lactamase Variant in Klebsiella pneumoniae Isolates from Nijmegen, The Netherlands
- 1 January 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (1) , 309-11
- https://doi.org/10.1128/aac.45.1.309-311.2001
Abstract
Four ceftazidime-resistant isolates of a Klebsiella pneumoniae strain were collected from intensive care unit patients in Nijmegen, The Netherlands. These isolates had TEM-29 and SHV-14 β-lactamases. SHV-14 is a novel variant, with two substitutions compared with the sequence of SHV-1: Ile8Phe and Arg43Ser. Its gene also had a silent C→T mutation at nucleotide 481. The SHV-14 enzyme had slightly higher V max rates than SHV-1 for oxyimino-aminothiazolyl cephalosporins, but this activity was insufficient for the enzyme to count as an extended-spectrum β-lactamase.Keywords
This publication has 11 references indexed in Scilit:
- SHV-13, a Novel Extended-Spectrum β-Lactamase, in Klebsiella pneumoniae Isolates from Patients in an Intensive Care Unit in AmsterdamAntimicrobial Agents and Chemotherapy, 2000
- Sequences of the Genes for the TEM-20, TEM-21, TEM-22, and TEM-29 Extended-Spectrum β-LactamasesAntimicrobial Agents and Chemotherapy, 1999
- Nomenclature of TEM beta-lactamasesJournal of Antimicrobial Chemotherapy, 1997
- Antibiotic resistance and production of extended-spectrum β-Mactamases amongst Klebsiella spp. from intensive care units in EuropeJournal of Antimicrobial Chemotherapy, 1996
- A functional classification scheme for beta-lactamases and its correlation with molecular structureAntimicrobial Agents and Chemotherapy, 1995
- SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patientsAntimicrobial Agents and Chemotherapy, 1995
- A standard numbering scheme for the class A β-lactamasesBiochemical Journal, 1991
- Cloning of SHV-2, OHIO-1, and OXA-6 beta-lactamases and cloning and sequencing of SHV-1 beta-lactamaseAntimicrobial Agents and Chemotherapy, 1990
- OHIO-1 beta-lactamase is part of the SHV-1 familyAntimicrobial Agents and Chemotherapy, 1990
- The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 dd-peptidase familyBiochemical Journal, 1988