INVIVO ANTISPASMODIC ACTIVITY OF SULOCTIDIL

  • 1 January 1976
    • journal article
    • research article
    • Vol. 221  (1) , 54-59
Abstract
Suloctidil was tested in vivo for its antispasmodic activity on peripheral and cerebral circulations. In the perfused dog hind limb preparation, suloctidil inhibited after 2 and 5 min, the vasospasm induced by norepinephrine or angiotensin; at equal dose, and at the same time intervals. It was more potent than cinnarizine and papaverine. BaCl2 induced spasms of the pial arteries of the rabbit were also rapidly alleviated by intra-arterial suloctidil (3.5 .mu.g/kg or more), in conditions where papaverine and vincamine were inactive.

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