Hemoglobin Adducts in Rats Chronically Exposed to Room-Aged Cigarette Sidestream Smoke and Diesel Engine Exhaust

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Abstract
Protein and DNA adducts are generally considered to be biologically effective dose markers that can indicate both carcinogen-induced cell damage and genetic susceptibility. Hemoglobin (Hb) adducts are not subject to specific enzymatic repair mechanisms like DNA modifications are; therefore, hemoglobin acts as a cumulative dosimeter capable of indicating exposure dose over the life-span of the erythrocytes, e.g., about 60 days in rats. Keywords Environmental Tobacco Smoke Inhalation Study Total Particulate Matter Diesel Engine Exhaust Nicotine Metabolite These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.